Rapalogs

What Are Rapalogs?

Rapalogs are drugs that work similarly to rapamycin, the most reliably life-extending drug.  Rapamycin was discovered in 1972 in a bacterium called Streptomyces hygroscopicus on the island of Rapa Nui (aka Easter Island).  It was initially developed as an antifungal, but later it was found that it inhibits the mTOR pathway, which regulates cell growth, cell proliferation, and cell survival. Recently, other drugs have been found which also inhibit mTOR.

Rapamycin is an immunosuppressant used to prevent organ transplant rejection; it has serious side effects in humans, including infections and low platelet counts, so it’s unlikely to be usable as an anti-aging preventative, though there are some studies suggesting that low-dose rapamycin may be safe.  

A few rapalogs have been found to have anti-aging effects in animals, but none have been shown to increase mouse lifespan so far.

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From rapalogs to anti-aging formula

Abstract

Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism.

[In this paper] I further suggest how rapamycin can be combined with metformin, inhibitors of angiotensin II signaling (Losartan, Lisinopril), statins (simvastatin, atorvastatin), propranolol, aspirin and a PDE5 inhibitor. Rational combinations of these drugs with physical exercise and an anti-aging diet (Koschei formula) can maximize their anti-aging effects and decrease side effects.

SOURCE: Oncotarget