How senescent cells drive skin aging
Cellular senescence is a fascinating process (which is why I chose a lab that researches it for my PhD), with both beneficial and detrimental consequences. A recent study shows a connection between melanocyte senescence and the induction of telomere dysfunction in nearby keratinocytes which is associated with epidermal atrophy. This increased with age. Using a senolytic in a human 3D culture model they were able to reduce this effect.