Epigenetic reprogramming

Lowering the epigenetic age

Several studies have shown that OSKM induction (where O stands for Oct4) lowers epigenetic age gradually.

Having discovered this gradual property of epigenetic reprogramming, we can now be cautiously optimistic that we will manage to find a safe therapeutic window (such as marked by a yellow box in the graph) – that is, a period of safe epigenetic rollback when the methylation profile of a cell has been returned to a younger state but the cell has not lost its functional characteristics (for example, a skin cell would remain a skin cell rather than getting dedifferentiated into a pluripotent cell).

READ MORE: Youthereum Genetics