Rejuvenating senescent cells

IMAGE CREDIT: Dr Eva Latorre, Harries Lab, Univ of Exeter

Senisca

The image above is a 48 hour timelapse of rejuvenating senescent primary human dermal fibroblast cells.

A major cause of age-related diseases and the aesthetic signs of ageing is the accumulation of senescent cells in aged tissues and organs; removal of such cells has been shown to be capable of bringing about ‘rejuvenation’ of function in people and animals. Scientists at Senisca have discovered a new and druggable means to reverse senescence through modulation of RNA splicing.

Levels of splicing factors change during ageing, compromising our ability to carry out this ‘fine tuning’ of gene expression. This is a fundamental reason why cells become senescent. Compromised molecular resilience is a major cause of the ill health and frailty that accompanies ageing.

Senisca has demonstrated that restoration of splicing factor levels to those seen in younger cells is able to effectively turn back the ageing clock in old cells, bringing about reversal of senescence.

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