Targeting growth factors
Cells produce protein growth factors in the precursor, or latent, form. For the mature growth factor to carry out its function, it must be activated (through molecular events) and separated from the prodomain.
Scholar Rock monoclonal antibodies target the prodomain of the precursor, or latent form of growth factors, and block the cage’s lock to inhibit activation. Given the much greater structural differences of the prodomain, we leverage this variance to achieve extraordinary selectivity.
With greater selectivity, we aim to minimize toxicity that have challenged approaches that target the mature form of growth factors.
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