Mitochondrial quality control
PINK1 is the cell’s surveillance system for damaged mitochondria. An unusual kinase, it only stabilizes in the presence of a depolarized mitochondrion; once stabilized, it activates a mitophagy pathway that leads to clearance of the damaged organelle.
PINK1 activation has been shown to oppose the inflammation, mtDNA mutations, and metabolic/proteostatic failures that can lead to cell death in disease.
LEARN MORE: Mitokinin