Cellular Senescence: A Translational Perspective

middle-aged woman

Abstract

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance, and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated secretory phenotype (SASP). Senescent cells accumulate in various tissues with aging and at sites of pathogenesis in many chronic diseases and conditions. The SASP can contribute to senescence-related inflammation, metabolic dysregulation, stem cell dysfunction, aging phenotypes, chronic diseases, geriatric syndromes, and loss of resilience.

Delaying senescent cell accumulation or reducing senescent cell burden is associated with delay, prevention, or alleviation of multiple senescence-associated conditions.

We used a hypothesis-driven approach to discover pro-survival Senescent Cell Anti-apoptotic Pathways (SCAPs) and, based on these SCAPs, the first senolytic agents, drugs that cause senescent cells to become susceptible to their own pro-apoptotic microenvironment. Several senolytic agents, which appear to alleviate multiple senescence-related phenotypes in pre-clinical models, are beginning the process of being translated into clinical interventions that could be transformative.

FULL TEXT: EBioMedicine

Eat like the Greeks

a fish

Excerpt

The Australian Biology of Ageing Conference hosted by the University of Sydney’s Charles Perkins Centre was told that in order for Australians to live longer they need to start eating like Greeks.

While this doesn’t come as news for most of us, researchers in the British Journal of Sports Medicine say that coronary heart disease is caused by chronic inflammation, which can be lowered with a Mediterranean-style diet rich in nuts, extra virgin olive oil, vegetables, and oily fish, according to a study by La Trobe University.

Not so long ago a study of around 800 men in the Concord Health and Ageing in Men project run out of Concord Hospital in Sydney revealed that when Greek or Italian migrant men tried to follow the Australian dietary recommendations they suffered.

“They didn’t do so well.”

FULL STORY: Neos Kosmos