Ian McCrae: Digital Me

Our bodies contain two terabytes of data. What if everyone involved in our healthcare – including us – could access that data and use it to make better lifestyle and treatment decisions? Precision medicine aims to answer that question and turn information into better health outcomes for everyone.

Deep learning for predicting pharmacological properties

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Abstract

Deep learning is rapidly advancing many areas of science and technology with multiple success stories in image, text, voice and video recognition, robotics, and autonomous driving. We demonstrate how deep neural networks trained on large transcriptional response data sets can classify various drugs to therapeutic categories solely based on their transcriptional profiles.

We used the perturbation samples of 678 drugs across A549, MCF-7, and PC-3 cell lines from the LINCS Project and linked those to twelve therapeutic use categories derived from MeSH. To train the deep neural network, we utilized both gene level transcriptomic data and transcriptomic data processed using a pathway activation scoring algorithm, for a pooled data set of samples perturbed with different concentrations of the drug for 6 and 24 hours.

In both pathway and gene level classification, the deep neural network achieved high classification accuracy and convincingly outperformed the support vector machine model on every multiclass classification problem, however, models based on pathway level data performed significantly better.

For the first time we demonstrate a deep learning neural net trained on transcriptomic data to recognize pharmacological properties of multiple drugs across different biological systems and conditions. We also propose using deep neural net confusion matrices for drug repositioning. This work is a proof of principle for applying deep learning to drug discovery and development.

FULL TEXT: Molecular Pharmaceutics