For decades, the attention of the scientific community was focused on the central dogma of biology — the decoding of the genetic information embedded in DNA. Little research was dedicated to how proteins are degraded and removed from cells.
Enter onto the scene a young graduate student, Aaron Ciechanover, who with his mentor Avram Hershko, uncovered the complex and elegant ubiquitin proteolytic system. For his discovery, Dr. Ciechanover shared in the 2004 Nobel Prize in Chemistry with Hershko and Irwin Rose. Watch the complete interview for more stories about being a member of the Pontifical Academy of Sciences, the magic of “A-ha” moments, and the conflict between religion and Darwinism.