Senotherapeutics are therapeutics strategies that target cellular senescence. These strategies can work by killing senescent cells (senolytics), inhibiting the proinflammatory secretory phenotype of senescent cells (senomorphics) or by activating our endogenous senolytic systems (immune surveillance). But what even are senescent cells, how do senolytics work, and what current human clinical trials provide supporting data?
What are the primary causes of aging?
In a previous video I introduced the different hallmarks of aging. These hallmarks can be split into three categories. We will look just at the primary causes of aging, the first category, otherwise referred to as the primary causes of damage in a cell.
NMN and aging
NAD+ levels decline as we age. There is some evidence from studies in model organisms that restoring NAD+ levels can increase lifespan/healthspan. One way to restore NAD+ levels is through NMN supplements, which is a precursor to NAD+. In this video, I will go into more detail regarding this and also look at why it could be beneficial and when are the potentially best times for NMN to be taken.
Intermittent fasting (dawn to sunset)
Well firstly, it turns out I cannot spell intermittent, but i do like learning the hard way … Anyway, here I will describe a recent study that looked at proteome changes when healthy participants fasted more than fourteen hours a day, for thirty consecutive days.
This video will look at the new technology to perform precise genome editing, prime editing and will look at how the method works and how it differs from the canonical CRISPR-Cas9 system.
How senescent cells drive skin aging
Cellular senescence is a fascinating process (which is why I chose a lab that researches it for my PhD), with both beneficial and detrimental consequences. A recent study shows a connection between melanocyte senescence and the induction of telomere dysfunction in nearby keratinocytes which is associated with epidermal atrophy. This increased with age. Using a senolytic in a human 3D culture model they were able to reduce this effect.
Hallmarks of aging?
What are the hallmarks of aging? Why is it over time cells become less functional? This video will introduce you to the nine different hallmarks of aging including the primary causes of damage, the responses to the damage and the systemic hallmarks.
Did you know that when you eat is just as important as what you eat? Why? When is best to eat? Why does it matter? In this video i discuss intermittent fasting (IF), the different types of IF compare it to calorie restriction, look at the health benefits and human clinical trial studies, discuss some problems and practical considerations and discuss a future outlook.
Removing senescent cells
Senescent cells accumulate with age. Studies have shown that removing senescent cells can alleviate symptoms of aging. However, a recent study has put this into question.
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