Senolytics vs. senomorphics

Senotherapeutics are therapeutics strategies that target cellular senescence. These strategies can work by killing senescent cells (senolytics), inhibiting the proinflammatory secretory phenotype of senescent cells (senomorphics) or by activating our endogenous senolytic systems (immune surveillance). But what even are senescent cells, how do senolytics work, and what current human clinical trials provide supporting data?

NMN and aging

NAD+ levels decline as we age. There is some evidence from studies in model organisms that restoring NAD+ levels can increase lifespan/healthspan. One way to restore NAD+ levels is through NMN supplements, which is a precursor to NAD+. In this video, I will go into more detail regarding this and also look at why it could be beneficial and when are the potentially best times for NMN to be taken.

How senescent cells drive skin aging

Cellular senescence is a fascinating process (which is why I chose a lab that researches it for my PhD), with both beneficial and detrimental consequences. A recent study shows a connection between melanocyte senescence and the induction of telomere dysfunction in nearby keratinocytes which is associated with epidermal atrophy. This increased with age. Using a senolytic in a human 3D culture model they were able to reduce this effect.

Intermittent fasting

Did you know that when you eat is just as important as what you eat? Why? When is best to eat? Why does it matter? In this video i discuss intermittent fasting (IF), the different types of IF compare it to calorie restriction, look at the health benefits and human clinical trial studies, discuss some problems and practical considerations and discuss a future outlook.